Abstract
Drug candidates with low aqueous solubility and low permeability are increasingly common in modern drug discovery programs. These properties, however, are problematic for the oral administration of these drugs as the intestinal absorption and uptake in blood will be hampered. Dissolving these drugs in lipid-based formulations (LBFs) can overcome the solubility barrier and polymers may be added to increase drug absorption. Little is known about the driving forces of absorption from these LBFs in the presence of polymers. This thesis describes the development of in vitro, in vivo, and computational models to understand this process.
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