Novel method for the prediction of distribution and elution characteristic of several drugs in cellulose diacetate-water system: Interaction between mixed solvent and cellulose diacetate

Abstract

Drug-loaded cellulose diacetate (CDA) membranes were prepared by dissolving cellulose diacetate in a mixed solvent of acetone and ethanol, adding the drug to it, pouring it on a glass plate and evaporating the solvent. In this study, it was prepared CDA membranes varying composition of the mixed solvent (the mass ratio of acetone (ACE) to ethanol (EtOH)) and investigated their microstructure and performance.The release properties of drugs in drug-loaded CDA membranes were examined in correlation with the composition of the mixed solvent and a method to be able to predict the release properties of drugs was proposed. Penicillin G potassium, streptomycin sulfate and ampicillin were used as drugs. The microstructure of the membranes was determined using SEM analysis and the release properties of drugs were measured using spectrofluorophotometer. It was shown that the composition of the mixed solvent can have a significant effect on the overall performance of CDA membrane. The intrinsic viscosity measurements and solubility parameter analysis proved that the intrinsic viscosity of CDA in polymer solutions with mixed solvents and the solubility parameter difference (Δδ) between mixed solvents and CDA were relative with the release properties of drugs. The release rates of drugs from the membrane related to △δ directly and the intrinsic viscosity inversely. Therefore, the release rates of drugs from CDA membrane can be controlled by changing the composition of the solvent used for the preparation of the polymer membrane.