Abstract
In this issue of Structure, Kori etal. (2019) report the crystal structure of a lysine-methylated non-histone peptide from DNA ligase 1 (LIG1K126me3) bound to the UHRF1 tandem Tudor domain (TTD). LIG1K126me3-TTD exhibits strong interactions involving peptide residues K120 to K126me3, regulated by phosphorylation, which affects the conformation of UHRF1.
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