Abstract
The emerging Corona virus strain (severe acute respiratory syndrome corona virus-2 (SARS-CoV-2)) harbors intricate in the development of corona virus infection (COVID-19)-induced pneumonia and subsequently ameliorates lung infection. Genome sequence and interventions reveal proximal resemblance of corona virus strain COVID-19 with severe acute respiratory syndrome (SARS), transmittable to bats, suggesting similar primary hosts in the spread of infection. However, potential rapid human-to-human transmission has caused therapeutic challenges in treating a wide range of humans suffering from corona virus all over the world. However, up to now, no direct vaccines or antiviral drugs are available to treat COVID-19. Previously designed antiviral drugs and convalescent plasma are undergoing investigations as treatment for COVID-19 infected patients. Therapeutic challenges with regards to COVID-19 have prompted scientists to develop fruitful remedies to combat the pathogen. In this review, we address the role of current ongoing therapeutic strategies, , and complex mechanisms of adaptive immune system (B and T cells) to respond to viruses. Furthermore, we illustrate the current challenges in the treatment of COVID-19, managerial strategies, and ongoing and future perspectives.
Highlights
We address the role of current ongoing therapeutic strategies, immunogenomics, and complex mechanisms of adaptive immune system (B and T cells) to respond to viruses
Coronaviruses, especially severe acute respiratory synsdrome-2 (SARS-CoV-2), are minute singlestranded micron sized RNA particles 1, harboring intricate capability to induce lung infection and pneumonia in humans 1; they are ordered in the Coronaviridae family 2
Different inculcations revealed that mortality parameters are dependent on physical health, age, immune mechanism, and gender discriminationranging from 0.3% to 15% 10,11
Summary
Coronaviruses, especially severe acute respiratory synsdrome-2 (SARS-CoV-2), are minute singlestranded micron sized RNA particles 1, harboring intricate capability to induce lung infection and pneumonia in humans 1; they are ordered in the Coronaviridae family 2. Genome sequence and phylogenetic interventions reveal proximal resemblance of corona virus strain COVID-19 with severe acute respiratory syndrome (SARS), transmittable to bats, suggesting similar primary hosts in the spread of infection. Designed antiviral drugs and convalescent plasma are undergoing investigations as treatment for COVID-19 infected patients.
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