Abstract
A new particulate drug delivery system with gelatin matrix containing Ibuprofen as a model drug molecule was developed for an epidermis drug prolonged release. Gelatin films containing Ibuprofen-loaded poly-epsilon-caprolactone (PCL) microspheres have been developed on evaporation of organic solvent from an oil-in-water emulsion followed by cross-linking. The microspheres were characterized for particle size, encapsulation efficiency, and surface morphology. Water uptake, matrix erosion, and drug release profile of the microsphere-film system were investigated. The results indicated that drug-loaded microspheres introduced in this system successfully prolonged drug release time. This kind of microsphere-film system combined good adhesion, typical for gelatin films, with the sustained release performance of PCL microspheres.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: Journal of Biomedical Materials Research Part B: Applied Biomaterials
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
