Abstract
Liposome-based delivery systems have been studied and used more frequently in recent years due to their advantages, such as low toxicity, specificity, and the ability to protect the encapsulated substance from environmental factors, which could otherwise degrade the active compound and reduce its effectiveness. Given these benefits, many researchers have encapsulated polyphenols in liposomes, thus increasing their bioavailability and stability. Similarly, polyphenols encapsulated in liposomes are known to produce more substantial effects on targeted cells than unencapsulated polyphenols, while having minimal cytotoxicity in healthy cells. Although polyphenols play a role in preventing many types of disease and generally have beneficial effects on health, we solely focused on their chemopreventive effects on cancer through liposomes in this review. Our goal was to summarize the applicability and efficacy of liposomes encapsulated with different classes of polyphenols on several types of cancer, thus opening the opportunity for future studies based on these drug delivery systems.
Highlights
IntroductionPublisher’s Note: MDPI stays neutral with regard to jurisdictional claims in published maps and institutional affiliations
Received: 2 August 2021Accepted: 16 September 2021Published: 22 September 2021Publisher’s Note: MDPI stays neutral with regard to jurisdictional claims in published maps and institutional affiliations.Licensee MDPI, Basel, Switzerland.Polyphenols are a large group of secondary metabolites, consisting of one or more aromatic rings to which one or more hydroxyl groups are attached [1]
A study by De Pace et al (2013) concluded that EGCG encapsulated in chitosan-coated nanoliposomes had antiproliferative and proapoptotic effects in MCF7 human breast cancer cells at concentrations of 10 μM or lower, whereas free EGCG had no positive effects at such concentrations
Summary
Publisher’s Note: MDPI stays neutral with regard to jurisdictional claims in published maps and institutional affiliations. The industry is interested in the extraction and characterization of polyphenols from natural sources to employ their potential bioactive properties Polyphenolic substances such as phenolic acids, flavonoids, anthocyanins, and tannins can all be used as biomarkers for chemotaxonomic classification or fruit quality markers because of their potential health advantages [4]. We review the most important polyphenols in each class, outline the effect produced in their free form, and describe the effects produced by their liposomal formulations In this way, we open the opportunity for future studies based on these drug delivery systems, which are the future in cancer therapy.
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