Abstract
Four novel isoquinoline alkaloids crispine B–E ( 2– 5 ), along with a new natural isoquinoline alkaloid, crispine A ( 1 ), were isolated from Carduus crispus, and the structures were elucidated on the basis of spectroscopic data. Crispine A and B are alkaloids with pyrrolo-[2,1- a]isoquinoline skeleton and crispine C–E are isoquinoline alkaloids with guanidinyl group. All compounds were evaluated for their cytotoxic activity ad compound 2 showed certain cytotoxic activity against some human-cancer lines in vitro.
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