Abstract
The use of biopolymers for the development of eco-friendly textile materials for medical and health care sector is now essential so as to minimize the infection due to harmful bacteria, especially for skin injury. The present research works are aimed at developing sustainable nano-structured textile material treated with tetrahydroxy curcumin and evaluate its application in the areas of wound management. Stable oil in water nanoemulsion of tetrahydroxy curcumin derivative was developed to improve its solubility using high-pressure homogenization technique. Textile material was impregnated with optimized nanoemulsion having particle size distribution 100–300 nm, zeta potential −30.1–−31.1 mV and drug content 80–83.3% by exhaust method using cyclodextrin and polycarboxylic acid as a cross-linking agent. Treated sample was observed to be more effective against B. Subtilis and E.Coli when evaluated for antimicrobial activity. The results were optimized using response surface methodology. It was observed that, 0.5% nanoemulsion at 100 °C for 15-min period of time shows maximum inhibition.
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