Abstract
SummaryOsteosarcomas are rare malignant bone tumors, most frequently occurring in children as well as adolescents and young adults. Therapy of initially localized disease consists of neoadjuvant chemotherapy followed by surgical resection and adjuvant chemotherapy. Osteosarcomas often present relapses, most commonly lung metastases. Treatment of isolated lung metastasis most commonly includes surgical resection. The correct adjuvant treatment option is still under investigation. In this manuscript we describe the clinical course of an osteosarcoma patient and give a review of the literature regarding current standard treatment for localized as well as pulmonary metastatic disease.
Highlights
Osteosarcomas are rare malignancies, which most commonly occur in children as well as adolescents and young adults, aged between 15–25 years [1]
We present the case of a young patient undergoing local surgery, chemotherapy as well as therapy with novel agents for recurring osteosarcoma
Watch and wait strategy is the treatment of choice in relapsed osteosarcoma patients with lung metastasis after R0 resection [7]
Summary
Osteosarcomas are rare malignancies, which most commonly occur in children as well as adolescents and young adults, aged between 15–25 years [1]. Localized osteosarcoma is generally treated with neoadjuvant chemotherapy followed by surgical resection and adjuvant chemotherapy [2, 3]. Osteosarcomas frequently develop isolated pulmonary relapses, which are commonly treated with complete metastasectomy if possible, even in consecutively relapsed disease [4, 5]. Data on systemic treatment options after pulmonary re-
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