Abstract
Calcium phosphate-based materials have been considered and widely developed as a promising candidate for bone repair and regeneration. With an aim to allow a better balance between resorption and degradation, novel beta-tricalcium and hydroxyapatite (β-TCP/HA) biphasic calcium phosphate (BCP) microspheres with different surface topographies were successfully prepared in this study. Results revealed that the surface topography structure of prepared BCP microspheres could be adjusted by tuning phosphoric acid concentrations and pH values. In vitro cytocompatibility has also been evaluated by CCK-8 and live/dead staining. Moreover, the potential applications of the obtained BCP microspheres as drug delivery were investigated by using the doxycycline as a model drug. All the results have demonstrated that utilizing the spherical calcium carbonate as a hard template is an effective strategy for synthesizing advanced β-TCP/HA BCP microspheres with controllable surface topography, which holds tremendous promise for bone regeneration and drug delivery applications.
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