Abstract
Flavivirus is a genus of arthropod-transmitted viruses of the family Flaviviridae, and in Brazil, up to eleven different Flavivirus have been isolated. We collected blood from farmers in the municipality of Theobroma, which is located 320km from the City of Porto Velho, the former capital of the Brazilian State of Rondônia. For viral isolation, we used newborn mouse brain, followed by RT-PCR with specific universal Flavivirus primers. We obtained fragments 958bp and 800bp in length. Based on BLAST, these sequences were 91% similar to a sequence of Cacipacore virus.
Highlights
The genus Flavivirus is composed of arthropod-transmitted viruses belonging to the Flaviviridae family[1]
Eleven flaviviruses are known to occur in Brazil: Bussuquara virus (BSGV), Cacipacore virus (CPCV), dengue virus (DENV-1, 2, 3, and 4), Iguape virus (IGUV), Ilheus virus (ILHV), Rocio virus (ROCV), Saint Louis encephalitis virus (SLEV) and yellow fever virus (YFV)
Reverse transcription-polymerase chain reaction (RT-PCR) methods using universal primers have been described for certain flaviviruses[3,4,5,6,7]
Summary
The genus Flavivirus is composed of arthropod-transmitted viruses belonging to the Flaviviridae family[1]. Flavivirus comprises more than 70 viruses sharing common antigenic determinants and contains the first human virus to be isolated, yellow fever virus, which is the prototype virus of the genus. The diagnosis of Flavivirus infection has been done by virus isolation or serological testing.
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