Abstract
Magnetic Resonance imaging (MRI) guided focused ultrasound (FUS) has been shown to be able to safely ablate deep tissues in the brain in clinical settings resulting in reduction in recovery time and complications. Pre-clinical work has demonstrated that FUS energy deposition with intravascular micro-bubbles could be used also for non-invasive MRI-guided drug delivery into tumours and brain. The preclinical studies have shown significant survival benefits when FUS has been used to open the blood-brain-barrier (BBB) for large molecular chemotherapy agents, antibodies and natural killer cells. Effective and local delivery of nanoparticles and viral vectors has also been shown.
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