Abstract
Objective To study the Src-activating and signaling molecule (Srcasm) expression regulated by Notchl in human esophageal squamous cell carcinoma (ESCC) TE1 cell line.Methods We transfected pcDNA3.1-Srcasm plasmid DNA (2 μg),pcDNA3.1-Srcasm plasmid NDA (2 μg),double (pcDNA3.1-Notch1 plasmid DNA 1 μg and pcDNA3.1-Srcasm plasmid DNA 1 μg) and mock (2 μg) into TE1 cells and examined Notch1/Srcasm expression by using Western blotting.Results Notch1 increased the Srcasm protein expression in TE1 cells.Conclusion Notch1 may act as a positive regulator of Fyn in human ESCC,and play an important role in human ESCC progress. Key words: Esophageal neoplasms ; Carcinoma, squamous cell; Notch1 ; Src-activating and signaling molecule
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
