Abstract
It has been known for many years that an acute intercurrent infection has a beneficial effect on certain chronic and subacute diseases. In dementia paralytica it had often been observed that a remission developed under such circumstances, and it was this observation that led Jauregg to treat patients with this condition by inoculating them with malaria. Wagner von Jauregg 1 published his results with malarial treatment in dementia paralytica in 1918 and 1922; from then on, this method became an accepted therapeutic aid throughout the world. In ophthalmology the same premise holds true; many intra-ocular lesions are benefited by the presence of fever. To induce a rise in temperature with leukocytosis, many foreign substances have been injected; those most commonly used are milk, diphtheria antitoxin and typhoid vaccine. There are numerous others, and apparently none is entirely satisfactory. Petersen 2 cited the following as having been used at
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