Abstract
Let F(x) and F(x+θ) be log dose-response curves for a standard preparation and a test preparation, respectively, in a parallel quantal bioassay designed to test the relative potency of a drug, toxicant, or some other substance, and suppose the form of F is unknown. Several estimators of the shift parameter θ or relative potency, are compared, including some generalized and trimmed Spearman-Karber estimators and a non parametric maximum likelihood estimator. Both point and interval estimation are discussed. Some recommendations concerning the choices of estimators are offered.
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