Nonlinear Magnetochemical Effects in Nanotherapy of Walker-256 Carcinosarcoma.

Abstract

The biological and medical aspects of magnetochemical effects in nanotherapy of tumors remain poorly studied. The present paper investigates the influence of nonlinear magnetochemical effects of anisotropic magnetic nanodots on an animal tumor model. The magnetic properties and electron spin resonance spectra of magnetic nanodots and doxorubicin were investigated after mechano-magnetochemical synthesis. The results obtained from the analysis of nonlinear kinetics and survival in Walker-256 carcinosarcoma-bearing animals found a nonlinear dependence between the value of the growth factor, braking ratio, survival rate, tumor redox state, and the treatment by the magnetic nanodot combined with a nonuniform constant magnetic field. To quantify the heterogeneity in microphotographs of Walker-256 carcinosarcoma sections, we applied the entropy parameter. The control (no treatment) group showed the greatest heterogeneity. The lowest value of tumor heterogeneity among animals given treatment was found in groups with the minimum growth factor. Similarly, the lowest entropy value was found in muscle tissue taken from inoculation areas of the tumor. The evidence from this study concluded that inhomogeneous constant magnetic fields with different strength applied to heterogeneous tumor tissues induced different magnetic anisotropy in the magnetic nanodot which had a significant influence on the nonlinear kinetics, redox state, and histological pattern of the tumor.