Abstract
Preimplantation genetic testing for aneuploidy (PGT-A) is currently performed via analyses of trophectoderm (TE) biopsies. Concerns regarding the safety of TE biopsy and the technical skill required to perform the procedure have led to increased interest in noninvasive preimplantation genetic testing for aneuploidy (niPGT-A). The noninvasive testing modality assesses an embryo’s genetic composition indirectly by analyzing spent culture media. This study begins the validation process of a commercially available assay by investigating: 1) the prevalence of DNA amplification failure with niPGT-A compared to TE biopsy; 2) factors affecting amplification failure with niPGT-A, and 3) the frequency of discrepant results between niPGT-A and traditional PGT-A.
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