Abstract
A spectral domain optical coherence tomography (SD-OCT) system and an oral imaging probe have been developed to visualize the microstructural morphology and microvasculature in the human oral cavity. Structural OCT images of ex vivo pig oral tissues with the histology of the same sites were acquired and compared for correlations. Structural in vivo OCT images of healthy human tissue as well as a pathologic site (ulcer) were obtained and analyzed based on the results of the ex vivo pig study, drawing on the similarity between human and swine oral tissues. In vivo Doppler and speckle variance OCT images of the oral cavity in human volunteers were also acquired, to demonstrate the feasibility of microvascular imaging of healthy and pathologic (scar) oral tissue.
Highlights
Optical coherence tomography (OCT) is a micrometer-scale-resolution imaging modality which provides depth resolved images of biological tissue to ~2 mm beneath the tissue surface [1]
Both swept-source OCT (SS-OCT) and spectral domain optical coherence tomography (SD-OCT) have been used for oral imaging [6,7], which is the focus of the current study
Due to the similarity of pig and human oral tissues, this served as a reference for interpreting the structural OCT results of the in vivo human study
Summary
Optical coherence tomography (OCT) is a micrometer-scale-resolution imaging modality which provides depth resolved images of biological tissue to ~2 mm beneath the tissue surface [1]. Use of optical fiber technology has enabled the development of compact OCT systems with localized optical probes [4] suitable for various clinical applications, such as gastrointestinal [3] and intravascular imaging [5]. A single detector is used to detect the back-scattered light of different wavelengths [1]. In SD-OCT, as employed in the current study, a broad bandwidth light source is used and the back-scattered signal is detected by a spectrometer-CCD camera system [1]. Both SS-OCT and SD-OCT have been used for oral imaging [6,7], which is the focus of the current study
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