Abstract
The development of electrospray (ESI) and matrix-assisted laser desorption (MALDI) ionization techniques for the transformation of proteins and nucleic acids into gas phase ions has reinvigorated mass spectrometry in the biological sciences. Gas-phase ions generated using electrospray ionization are believed to retain their solution structures during the desolvation process.(1) As a result, it is now possible to detect and characterize the structure and properties of molecules too large for study via solution techniques such as NMR spectroscopy. ESI and MALDI ionization provide high sensitivity and transmission efficiency for detection of fmole quantities using FTICR, quadrupole ion trap, or conventional quadrupole mass spectrometers.
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