Abstract
The development of electrospray (ESI) and matrix-assisted laser desorption (MALDI) ionization techniques for the transformation of proteins and nucleic acids into gas phase ions has reinvigorated mass spectrometry in the biological sciences. Gas-phase ions generated using electrospray ionization are believed to retain their solution structures during the desolvation process.(1) As a result, it is now possible to detect and characterize the structure and properties of molecules too large for study via solution techniques such as NMR spectroscopy. ESI and MALDI ionization provide high sensitivity and transmission efficiency for detection of fmole quantities using FTICR, quadrupole ion trap, or conventional quadrupole mass spectrometers.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
