Abstract
The effect of camphor, a monoterpenoid, on catecholamine secretion was investigated in bovine adrenal chromaffin cells. Camphor inhibited [ 3H]norepinephrine ([ 3H]NE) secretion induced by a nicotinic acetylcholine receptor (nAChR) agonist, 1,1-dimethyl-4-phenylpiperazinium iodide (DMPP), with a half-maximal inhibitory concentration ( ic 50) of 70 ± 12 μM. In addition, camphor inhibited the rise in cytosolic calcium ([Ca 2+] i) and sodium ([Na +] i) induced by DMPP with ic 50 values of 88 ± 32 and 19 ± 2 μM, respectively, suggesting that the activity of nAChRs is also inhibited by camphor. On the other hand, binding of [ 3H]nicotine to nAChRs was not affected by camphor. [Ca 2+] i increases induced by high K +, veratridine, and bradykinin were not affected by camphor. The data suggest that camphor specifically inhibits catecholamine secretion by blocking nAChRs without affecting agonist binding.
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