Abstract
ABSTRACT Non-thyroxine (T4) iodine release from the thyroid gland has been estimated in six euthyroid volunteer subjects undergoing experimental falciparum malaria infection. Values for non-T4 iodine secretion during a control period were >300% of estimates for T4-iodine release. During the period of acute clinical illness, non-T4 iodine release decreased to levels equivalent to those for T4-iodine secretion. During convalescence, an increased secretion of both T4 and non-T4 iodine was observed. T4-iodine secretion during recovery exceeded control values, whereas non-T4 iodine release did not attain control levels. These data suggest a greater efficiency of thyroidal iodine metabolism following recovery from the suppressive effects of malarial infection on the thyroid gland.
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