Abstract
Objective: To investigate the effect of vitamin-D deficiency on ocular surface clinical parameters in Non-Sjögren dry eye patients. Material and Methods: Forty patients with serum vitamin D deficiency and 24 control subjects with normal vitamin D levels were included in this study. Ocular surface disease index (OSDI) questionnaire, tear break-up time (TBUT), corneal fluorescein staining and Schirmer 1 test without topical anesthesia were performed to all patients. Results: The median vitamin-D levels were 10.5 (9.5-12.5) ng/mL in study and 24.5 (17.6-35.2) ng/mL in the control group (p<0.001). The median OSDI scores were 27.77(18.75-37.50) in study, 8.33 (6.25-28.41) in control group (p =0.071). The mean TBUT were 5.18±2.15 and 7.36±3.10 seconds and Schirmer scores were 12.18±6.44 and 18.57±8.99 mm in the study and control groups. TBUT scores and Schirmer 1 results of the study group were significantly lower than the control group (p=0.01 and 0.007 respectively). There was also a significant difference in corneal fluorescein staining score between groups (p<0.001). Conclusion: Vitamin-D deficiency seems to have an effect on ocular surface parameters however does not influence OSDI scores in patients with Non-Sjögren dry eye syndrome.
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