Non-functional pancreatic neuroendocrine tumours: ATRX/DAXX and alternative lengthening of telomeres (ALT) are prognostically independent from ARX/PDX1 expression and tumour size

Wenzel M Hackeng ,Joo Young Kim,Els Nieveen Van Dijkum,Vincenzo Corbo,Gerlof D Valk ,Claudio Luchini,Massimo Milione,Samantha Bersani,Adam Slivka,Aldo Scarpa,Roberto Salvia,Rohit Das,Nathan Bahary,David A Geller ,Andrea Mafficini,Koen M.a Dreijerink ,Rita T Lawlor ,J Wallis Marsh ,Christopher M Heaphy ,Michèle Milella ,Seung Mo Hong ,Michael A Nalesnik ,Melissa E Hogg ,Alessandro Paniccia,Charlotte M Heidsma ,Kevin Mcgrath,Marina N Nikiforova ,Roderick J O’sullivan ,Sara Cingarlini,Amer H Zureikat ,Dengfeng Cao,Kenneth Lee,Randall E Brand ,Jennifer Chennat,Lodewijk A.a Brosens ,Jacqueline A Brosnan-Cashman ,Melanie Ongchin,G Johan A Offerhaus ,Savreet Sarkaria,Ta‐Chiang Liu ,Boris Rusev,Menno R Vriens ,Luca Landoni,Antonio Pea,Kenneth E Fasanella ,James F Pingpank ,You Na Sung ,Herbert J Zeh ,Michelle Heayn,Muaz Aijazi,Xinhui Han ,Folkert H.m Morsink ,Harkirat Singh,Asif Khalid,Soyeon An,Aatur D Singhi

doi:10.1136/gutjnl-2020-322595

Non-functional pancreatic neuroendocrine tumours: ATRX/DAXX and alternative lengthening of telomeres (ALT) are prognostically independent from ARX/PDX1 expression and tumour size

Wenzel M Hackeng , Joo Young Kim + Show 54 more

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https://doi.org/10.1136/gutjnl-2020-322595

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Journal: Gut	Publication Date: Apr 13, 2021
Citations: 75	License type: open-access

Affiliation: University Medical Center Utrecht, Utrecht University, Eulji University, Amsterdam University Medical Centers, University of Verona, Fondazione IRCCS Istituto Nazionale dei Tumori, University of Pittsburgh Medical Center, West Virginia University, Boston University, Johns Hopkins University, Asan Medical Center, University of Ulsan, Ulsan College, NorthShore University HealthSystem, University of Pittsburgh, Washington University in St. Louis, The University of Texas Southwestern Medical Center, Incheon St. Mary's Hospital, UPMC Health System

#Alternative Lengthening Of Telomeres #Non-functional Pancreatic Neuroendocrine Tumours + Show 8 more

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ObjectiveRecent studies have found aristaless-related homeobox gene (ARX)/pancreatic and duodenal homeobox 1 (PDX1), alpha-thalassemia/mental retardation X-linked (ATRX)/death domain-associated protein (DAXX) and alternative lengthening of telomeres (ALT) to be promising prognostic...

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