Abstract
BackgroundMucoepidermoid carcinoma (MEC) is a common cancer in the oral salivary gland malignancy, which mainly occurs in the parotid gland. The aim of this study is to identify independent prognostic factors and establish a nomogram model for parotid gland mucoepidermoid carcinoma (P-MEC) patients using the National Cancer Institute’s Surveillance, Epidemiology, and End Results (SEER) database.MethodPatients with P-MEC were selected from between 2004 and 2015. The overall survival (OS) and cancer-specific survival (CSS) rates were estimated using the Kaplan-Meier method with the log-rank test. Univariate and multivariate Cox proportional hazards regression analyses were performed to identify the independent prognostic factors.ResultsA total of 1,306 patients with P-MEC were enrolled. Age, grade, T stage, N stage, M stage, chemotherapy, and surgery type were independent prognostic factors for OS and CSS. A nomogram for OS was formulated based on these independent prognostic factors and validated using an internal bootstrap resampling approach, which showed that the nomogram exhibited a sufficient level of discrimination according to the C-index (0.877, 95% CI [0.855–0.898]).ConclusionSeveral prognostic factors for P-MEC were identified. The nomogram developed in this study accurately predicted the 5- and 10-year OS rates of American patients with P-MEC based on individual characteristics. Risk stratification using the survival nomogram can optimize individual therapies and follow-up.
Highlights
Mucoepidermoid carcinoma (MEC) is the most common salivary gland malignancy
Nomogram to predict the prognosis of parotid gland mucoepidermoid carcinoma: a population-based study of 1306 cases
Among the 1,306 cases, 660 (50.5%) patients were female, 680 (52.1%) patients had tumors originating from the right parotid gland, and 1,286 (98.5%) patients received surgery
Summary
Mucoepidermoid carcinoma (MEC) is the most common salivary gland malignancy. About 50% MEC occurs in the major salivary glands, with 70% in the parotid glandHow to cite this article Sun J, Sun Y, Yang F, Zhou Q, Liu W, Cheng Y, Wu X, Chen T, Li R, Huang B, Att W, Yu Y, Bi W. 2019. Mucoepidermoid carcinoma (MEC) is the most common salivary gland malignancy. Nomogram to predict the prognosis of parotid gland mucoepidermoid carcinoma: a population-based study of 1306 cases. Postoperative radiotherapy has shown a survival benefit in patients with major salivary gland carcinoma. Mucoepidermoid carcinoma (MEC) is a common cancer in the oral salivary gland malignancy, which mainly occurs in the parotid gland. The aim of this study is to identify independent prognostic factors and establish a nomogram model for parotid gland mucoepidermoid carcinoma (P-MEC) patients using the National Cancer Institute’s Surveillance, Epidemiology, and End Results (SEER) database. Grade, T stage, N stage, M stage, chemotherapy, and surgery type were independent prognostic factors for OS and CSS. The nomogram developed in this study accurately predicted the 5- and 10-year OS rates of American patients with P-MEC based on individual characteristics. Risk stratification using the survival nomogram can optimize individual therapies and follow-up
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