Nocturnal cough in patients with sputum production

Abstract

864 Vol 350 • September 20, 1997 recommended to be reapplied frequently throughout the day therefore the daily amount used in practice is likely to exceed 2 mg/cm. Over the period of application only 1–2% of sunscreen in the applied product was absorbed, therefore the sunscreen content of the topical product was relatively unchanged over the period of application. It is likely that given the apparent small depletion of sunscreen in the applied formulation on the skin, a similar amount would have been absorbed if a product application density of 2 mg/cm had been used. However, had there been substantial depletion of sunscreen in the product (ie, greater than 10%) over the period of application the density of product applied to the skin would have been critical. Our results suggest that sunscreens should not be the sole method of sun protection. It would be prudent not to apply oxybenzone to large surface areas of skin for extended and repeated periods of time, unless no alternative protection is available. There may be an additional concern for young children who have less well-developed processes of elimination, and have a larger surface area per body weight than adults, with respect to systemic availability of a topically applied dose.