Abstract
Chitosan is of great interest because it is biocompatible, biodegradable and abundant in nature. Accurate characterization of modified chitosan biopolymers is essential to optimize their usage. In our present work, we have tested the physicochemical characterization of 4 different types of chitosan biomaterials, which are classified into N , O -carboxymethylchitosan (NO-CMC) and Oligo-Chitosan (O-C). We have employed Fourier Transform Infrared Spectroscopy (FTIR) to analyze the functional groups and Scanning Electron Microscopy (SEM) to examine the scaffold membrane properties of each biomaterial. The FTIR analysis confirmed that a large number of alterations were made towards the NO-CMC group of chitosan. Meanwhile, most of the bands observed in the O-C group can generally be found in the standard model of chitosan. Shifting of the carbonyl group is only noticed in O-C group, which distinguishes both chitosan groups at 1644.20–1633.69 cm -1 peak.The NO-CMC and O-C groups, which have compressive porous structures, are able to support tissue and cell adherence via mechanical strength. Chitosan biopolymers, which vary from different grades and forms, are performing best when their unique properties are optimized. Hence, the study of these structurally modified chitosans and their characterization is very important to correlate their usage and properties in various fields.
Highlights
Biomaterials can be defined as any nondrug synthetic material that is used to restore, replace or imitate the original processes of damaged tissues and cells [1,2]
We have tested the physicochemical characterization of 4 different types of chitosan biomaterials, which are classified into N,Ocarboxymethylchitosan (NO-CMC) and Oligo-Chitosan (O-C)
Based on the Fourier Transform Infrared Spectroscopy (FTIR) analysis, most functional groups are absent for the NO-CMC type of chitosans in comparison to the O-C type
Summary
Biomaterials can be defined as any nondrug synthetic material that is used to restore, replace or imitate the original processes of damaged tissues and cells [1,2]. Chitosan biomaterials have been shown to exhibit and possess good biocompatibility, antimicrobial activity, biodegradability, hemostatic activity, antioxidant properties and drug delivery abilities [5,6,7,8,9]. These biomaterials have attracted more interest, and a variety of procedures have been proposed to produce standard modified chitosan biomaterials by altering the structure and the physical and chemical composition of chitosan polymers to generate distinct formulations of chitosan derivatives for various applications in the fields of biotechnology, tissue engineering, cosmetics, biomedicine, food and agriculture [10,11,12,13].
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