Abstract
Background: Acne vulgaris is a chronic inflammatory disease that affects the majority of the population at some point in their lifetime. Acne pathogenesis is multifactorial with four primary contributors that play a pivotal role in the formation of acne lesions: inflammation, androgeninduced sebum production, abnormal keratinization, and bacterial colonization. Recent studies have demonstrated the anti-inflammatory, anticarcinogenic, anti-diabetic, and anti-lipid properties of certain Polymethoxylated Flavones (PMF) derivatives.
Highlights
Acne is the most common skin condition in the United States of America, affecting 80% of people between 11 and 30 years of age [1,2]
Nobiletin and Mixture Polymethoxylated Flavones (PMF) down-regulated Peroxisome Proliferator-Activated Receptor (PPAR) gene expression and inhibited cytokines and immune receptors involved in the inflammatory response
Nobiletin and Mixture PMF inhibited the inflammatory cascade, androgenic pathway in 3D human epidermal tissue models compared to the vehicle-treated cells
Summary
Acne is the most common skin condition in the United States of America, affecting 80% of people between 11 and 30 years of age [1,2]. Acne vulgaris is a chronic inflammatory disease: factors in these conditions are the increased sebum production, hypercornification, and abnormal differentiation of keratinocytes of the upper part of the follicle. Acne pathogenesis is multi factorial with four primary factors that play a pivotal role in the formation of acne lesions: inflammation, androgen-induced sebum production, abnormal keratinization, and Journal of Clinical and Laboratory Medicine Open Access Journal bacterial colonization of Cutibacterium acnes in the pilosebaceous unit [5]. Acne pathogenesis is multifactorial with four primary contributors that play a pivotal role in the formation of acne lesions: inflammation, androgeninduced sebum production, abnormal keratinization, and bacterial colonization. Recent studies have demonstrated the anti-inflammatory, anticarcinogenic, anti-diabetic, and anti-lipid properties of certain Polymethoxylated Flavones (PMF) derivatives
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