Abstract
BackgroundSeveral environmental and genetic factors are associated with high levels of lipids in obese patients. Apolipoprotein B (ApoB) is the major protein component of low-density lipoproteins (LDL), very-low density lipoproteins (VLDL) and chylomicrons and plays a central role in lipid metabolism. Several apoB restriction fragment length polymorphisms (XbaI, EcoRI, MspI) have been reported to be associated with variation in lipid levels and obesity. To date, no data are available on the relationship between XbaI polymorphism and lipid levels in Egyptian populations. Following clinical profiling, 178 obese (body mass index [BMI] >25 kg/m2) and 178 age-matched non-obese (BMI ≤ 25 kg/m2) subjects were included in this case–control study. All samples were analysed for total cholesterol, triglycerides and HDL-cholesterol. Genetic analysis of apoB XbaI (X) was performed using Polymerase Chain Reaction-Restriction Fragment Length polymorphism (PCR-RFLP). The aim of this study was to assess the association of apoB XbaI gene polymorphism (X) and lipid profiles in obese and non-obese Egyptian populations.ResultsObese subjects demonstrated significantly higher values of waist-to-hip ratio, blood pressure, and total lipid. However, in our sample we did not find significant differences in apoB XbaI gene polymorphism (X) genotype or allele frequencies. Moreover, none of the studied lipid parameters showed any association with the gene polymorphism.ConclusionThis study reveals no significant association of apoB XbaI gene polymorphism (X) with obesity or lipid profiles in an Egyptian population.
Highlights
Obesity is a common, preventable and often underestimated, condition of clinical and public health importance in many countries
We have examined the genotypic and allelic frequencies and the effect of apoB XbaI polymorphism (X) on obesity and lipid profile in well-defined Egyptian obese and non-obese populations
Various studies have shown an association between the Apo B gene polymorphisms with lipoprotein subfractions (TC, low-density lipoproteins (LDL)-C, and TG) [21,22,23]
Summary
Preventable and often underestimated, condition of clinical and public health importance in many countries. In many societies, including Egypt, obesity has been viewed as a sign of wellbeing or high social status. This has effectively led to the denial, by (generally high status) health care professionals and the public, that obesity is a disease. Several environmental and genetic factors are associated with high levels of lipids in obese patients. Several apoB restriction fragment length polymorphisms (XbaI, EcoRI, MspI) have been reported to be associated with variation in lipid levels and obesity. No data are available on the relationship between XbaI polymorphism and lipid levels in Egyptian populations. The aim of this study was to assess the association of apoB XbaI gene polymorphism (X) and lipid profiles in obese and non-obese Egyptian populations
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