No association between rs6295 of and risk of migraine: Evidence from meta-analysis

Abstract

Migraine is considered a complex disorder with polygenic inheritance and is associated with a variant i.e., rs6295 has been hypothesized to be involved in determining the disease susceptibility. Therefore, in the present study we aimed to find the risk between the rs6295 and migraine susceptibility using a meta-analysis approach. The present study utilizes the PRISMA guideline to review existing literature to perform pooled analysis, and also includes quality assessment, association analysis, publication, and heterogeneity analysis using the NOS tool, OR with 95% CI, tests of Begg's with Egger's test, and χ2 based on Cochran's Q Test with I tests respectively. In the present study we didn’t observe any statistical association between the rs6295 and risk of migraine (allele: 1.01 [0.83-1.22], p-value=0.92). Further sub-grouping based on the clinical sub-type, no association was observed in either group i.e., MA (allele: 1.02 [0.73-1.40], p-value=0.90) and MWA (allele: 1.03 [0.75-1.41], p-value0.83). In the present analysis after critical analysis, it was observed that rs6295 didn’t pose any significant risk to the disease susceptibility.