Abstract
DearEditor, Accurate prediction of RA development in individuals at risk of RA remains challenging. Previous studies showed that musculoskeletal ultrasonography (US) abnormalities can help predict clinical arthritis development in at-risk individuals [1, 2]. However, performing US in every at-risk individual is not feasible due to time constraints, costs and high dependence on the examiner. Optimal spectral transmission (OST) imaging could be an objective, fast and low-cost alternative. It measures the transmission of light through tissue. Synovitis causes changes in the joint capsule and synovial fluid, decreasing light transmission [3]. In RA patients, OST correlated to US in detecting synovitis in the hand joints [4–8]. In at-risk individuals, OST might be an alternative for US to detect subclinical synovitis and possibly predict clinical arthritis. This is the first study of OST in an RA-risk population. To study the feasibility of OST in...
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