Abstract
Purpose: The currently prescribed analgesics for OA related pain do not always sufficiently reduce pain and can be associated with side-effects or can be contra-indicated. Other treatment options are therefore needed. An option may be duloxetine, a serotonin and norepinephrine reuptake inhibitor (SNRI). Duloxetine is hypothesized to reduce chronic pain by central inhibition of pain. Several placebo-controlled studies showed small to moderate effect of duloxetine. However, the effectiveness in a primary care setting is unknown.
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