Abstract
A single dose of N-methyl- N-nitrosourea (NMU) (100 mg/kg) reduces the labeling by [ 14C]orotate of rat kidney RNA by 40%, the maximum effect being reached at 1.5–3 h. The analysis of the acid-soluble pool revealed that this effect is due to an inhibition of the uptake of [ 14C]orotate into rat kidney. The decrease in the labeling by [ 14C]orotate of liver RNA is less marked and could be shown to result from an interference of NMU with the synthesis of pyrimidine nucleotides in the precursor pool. It is concluded that sublethal doses of NMU, although depressing DNA and protein synthesis, do not affect RNA synthesis in rat liver and kidney.
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