Abstract
A single dose of N-methyl- N-nitrosourea (NMU) (100 mg/kg) reduces the labeling by [ 14C]orotate of rat kidney RNA by 40%, the maximum effect being reached at 1.5–3 h. The analysis of the acid-soluble pool revealed that this effect is due to an inhibition of the uptake of [ 14C]orotate into rat kidney. The decrease in the labeling by [ 14C]orotate of liver RNA is less marked and could be shown to result from an interference of NMU with the synthesis of pyrimidine nucleotides in the precursor pool. It is concluded that sublethal doses of NMU, although depressing DNA and protein synthesis, do not affect RNA synthesis in rat liver and kidney.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
