Abstract
In biological systems where cogeneration of multiple reactive species occurs, nitric oxide (NO) will exacerbate oxidant injury via production of the potent oxidant ONOO- and can also exert tissue protectiveroles. Nitric oxide has proven to be a ubiquitous signal transduction molecule and apotent mediator of tissue injury because of its low molecular mass, volatility, lipophilicity, free radical nature, and diverse reactivities. The relative rates of production, sites of production and steady-state concentrations of reactive species, antioxidants and tissue mediators will critically influence the observed apparent toxic or protective effects of NO in biological systems. Development of a better understanding of the physiological roles of NO, coupled with detailed insight into NO regulation of oxygen radical-dependent reactions and the chemistry of -NO and ONOO-, should yield a more rational basis for the present and future therapeutic use of inhaled NO gas mixtures, NO donors and inhibitors of NO synthases.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
