Abstract
The effects of nitric oxide on the Ca 2+ channel currents of adult rat superior cervical ganglion neurons were investigated using the whole-cell patch-clamp technique. Nitric oxide-containing compounds sodium nitroprusside and S-nitroso- N-acetyl-penicillamine increased the amplitude of Ca 2+ currents by intracellular application. In addition, both sodium nitroprusside and S-nitroso- N-acetylpenicillamine reduced norepinephrine-induced inhibition of Ca 2+ currents. The results suggest that nitric oxide might be involved in the modulation of Ca 2+-dependent neurotransmission in sympathetic neurons.
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