Abstract
The kinetic and pharmacological properties of low voltage-activated (LVA) Ca2+ channels were studied in neurons of the laterodorsal (LD) thalamic nucleus in brain slices from 12-day-old rats. A homogeneous population of LVA Ca2+ channels was found in the tested neurons. LVA Ca2+ current evoked by a step depolarization from a holding potential more negative than −70 mV was found to be sensitive to nifedipine (Kd=2.6 (M). This current gained its maximum at −55 mV and demonstrated fast monoexponential decay with the time constant of 32.3±4.0 msec (n=15). Lanthanum (1 μM) effectively blocked LVA Ca2+ current, while nickel (25 μM) did not affect this current. It is concluded that the channels that, according to their pharmacological properties, provide the studied LVA Ca2+ current cannot be regarded as T-type Ca2+ channels and belong to some other type of LVA Ca2+ channels.
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