Abstract
Nicotinamide adenine dinucleotide (NAD) kinase(ATP:NAD+ 2′ phosphotransferase; EC 2.7.1.23) activity was measured in uterine endometrium from hormone-treated, chronically ovariectomized rats. After 3 days of priming with 5 μg estrone/day and 1 day of hormone deprivation (day 0), animals were injected daily for 1–5 days with (1) no hormone (C), (2) 1 ng estrone (E), (3) 2 mg progesterone (P), or (4) the two hormones combined (E+P). Decidual induction in similarly treated rats demonstrated the ability of the E+P treatment to generate a transient period of decidual sensitivity comparable to that of normal pseudopregnancy. NAD kinase activity was measured during days 2 through 6 of treatment and, additionally, 30 min after decidual induction on day 5 in animals treated with E, P, or E+P and on day 6 in animals with E+P. Kinetic parameters of NAD kinase were assessed on day 5 of treatment with E or E+P or 30 min after uterine trauma on day 5 of E+P treatment. NAD kinase activity increased over time after P and...
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