NI-19 USEFULNESS OF AMIDE PROTON TRANSFER IMAGE IN IMAGING DIAGNOSIS OF GLIOMA

Abstract

INTRODUCTIONAPT image is one of the imaging methods in MRI, and it is a molecular image that images the concentration of an amide group having an amino acid increasing in a tumor, and is expected to be clinically applied in the imaging diagnosis of glioma. on the other hand, MET-PET is useful for diagnosis of glioma because it is well accumulated in tumor cells. Based on the results of pathological diagnosis, we compared the two and verified that APT image is useful.METHODThe study included 36 patients who underwent APT image and MET-PET. (Glioma WHO2016 Grade:GII/III/IV,and Pseudoprogression). MET-PET was administered 370MBq/kg, and the accumulation ratio (TNR) of the tumor part to the normal part was measured. APT image measured APT signal with the region of interest at the tumor site.RESULTSAPT signal in all 36 cases was correlated with 2.19±0.94 and TNR with 2.61±1.55 (r=0.67,p<0.001).The discrimination accuracy between GII/III/IV and Pseudoprogression by APT signal was 84% sensitivity and 100% specificity at threshold 2.0.GII APT signal 2.30±0.43, TNR 4.02±2.12, GIII APT signal 2.67±0.69, TNR 2.81±0.72, GIV APT signal 2.78±0.61, TNR 3.37±1.28 in grade diagnosis At high grade, APT signal and TNR were high. The APT signal of the oligodendroglioma line (GII/III) was 2.44±0.7, the TNR was 3.78±1.51, the APT signal of the astrocytoma line (GII/III) was 2.69±0.51, and the TNR was 2.43±0.98.The oligodendroglioma lineage was lower in APT signal than the astrocytoma lineage, and the TNR was higher.DISCUSSIONAPT images are non-invasive, can easily provide important information, and have the same diagnostic potential as MET-PET. Although TNR of oligodendroglioma (GII/III) tends to be high, the APT signal which is not affected by the blood-brain barrier is consistent in measurement value and is useful for diagnostic imaging of glioma.