Abstract
New view in cell death mode: effect of crystal size in renal epithelial cells.
Highlights
In 2009, the Nomenclature Committee on Cell Death proposed a set of recommendations for the definition of distinct cell death morphologies and for the appropriate use of cell death-related terminology, including ‘apoptosis’, ‘necrosis’ and ‘mitotic catastrophe’.1 Of which, apoptosis and necrosis is always the most concern topic on cell death mode to researchers
Kidney stones are a common and frequently occurring disease, 470% of kidney stone patients suffer from urolithiasis caused by calcium oxalate (CaOx) stones, but the mechanism by which kidney stones are formed has not yet been completely clarified
In our new paper in Cell Death Discovery,[6] we comparatively investigated the differences of cell death mode induced by nano-sized (50 nm) and micron-sized (10 μm) calcium oxalate monohydrate (COM) and dihydrate (COD) to explore the cell death mechanism
Summary
In 2009, the Nomenclature Committee on Cell Death proposed a set of recommendations for the definition of distinct cell death morphologies and for the appropriate use of cell death-related terminology, including ‘apoptosis’, ‘necrosis’ and ‘mitotic catastrophe’.1 Of which, apoptosis and necrosis is always the most concern topic on cell death mode to researchers. In our new paper in Cell Death Discovery,[6] we comparatively investigated the differences of cell death mode induced by nano-sized (50 nm) and micron-sized (10 μm) calcium oxalate monohydrate (COM) and dihydrate (COD) to explore the cell death mechanism. Exposure to nano-/micron-sized COM and COD crystals triggered both apoptotic and necrotic cell death in renal epithelial cell lines.
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