Abstract
Herein, five new steroidal glycosides (Smilnipponicoside A-E) with five known congeners were isolated from the ethanol extracts of the rhizomes of Smilax nipponica Miq. Their structures were established by 2D NMR spectroscopic techniques (HMBC, HSQC, 1H,1H-COSY and NOESY), together with mass spectrometry, then comparison with the data in literature. The new compounds were subjected to evaluate anti-inflammatory in vitro. Compounds 1, 2 and 3 were found to have modest anti-inflammatory effects through suppression of TNF-α production in LPS-stimulated RAW 264.7 cells.
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