Abstract
The new compounds 2-methyl-6-isopropyl-7-hydroxymethyl naphthalene (1), oxyphyllenone H (2), epi-oxyphyllenone (6), (E)-labda-12,14-dien-15(16)-olide-17-oic acid (3), and two new natural products 4 and 5 were isolated from the ethyl acetate part of 95% ethanol extract of Alpinia oxyphylla, together with six known compounds 7–12. The inhibitory effects of compounds 1–12 on α-glucosidase were evaluated, and compounds 1, 3 and 6 showed moderate bioactive effect, with inhibitory rates of 10.3%, 10.0% and 11.5%, respectively, compared to the positive control acarbose (41.9%) at 20 µg/mL.
Highlights
Alpinia Oxyphylla Fructus is the dry ripe fruit of Alpinia oxyphylla Miq. (Zingiberaceae), which is widely distributed in South China
In the HMBC experiment (Figure 2), The correlations from H-1 to C-3, C-5 and C-10, from H-4 to C-5, C-6 and C-10, from H-8 to C-6, C-7 and C-10, from H-9 to C-5, C-7 and C-10 confirmed the existence a naphthalene ring; the long-range correlations from CH3-15 to C-1, C-2 and C-3 confirmed that the methyl group was anchored at C-2; the HMBC correlations from -CH2-14 to C-6, C-7 and C-8 determined the direct connection between the
C-14 and C-7; the correlations of H-11 with C-5, C-6 and C-7, of CH3-12/13 with C-6 displayed that the isopropyl group was connected with C-6
Summary
Alpinia Oxyphylla Fructus is the dry ripe fruit of Alpinia oxyphylla Miq. (Zingiberaceae), which is widely distributed in South China. (Zingiberaceae), which is widely distributed in South China. It has been used in Traditional Chinese Medicine (TCM) for the treatment of intestinal disorders, dieresis and dementia [1]. Previous phytochemical investigations of this medicinal plant have resulted in the isolation and identification of a series of sesquiterpenoids [2–6]. As. Molecules 2015, 20 part of our ongoing work on the discovery of new active secondary metabolites from this plant, four new compounds, namely 2-methyl-6-isopropyl-7-hydroxymethyl naphthalene [1], oxyphyllenone H [2], and epi-oxyphyllenone [6], the stereoisomer of synthesized compound [14] [7],. We reported the isolation and the structure elucidation of the new compounds and the inhibitory effects of all these compounds on α-glucosidase
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