Abstract
Poly(dodecanedioic acid-tetradecandioic acid) (P(DDDA-TA)) copolymers and poly(brassylic acid-pentadecandioic acid) (P(BA-PA)) copolymers have been prepared by melt polycondensation of the corresponding mixed anhydride prepolymers derived from dodecanedioic acid, brassylic acid, tetradecandioic acid and pentadecandioic acid. The copolymers were characterized by FT-IR, gel permeation chromatography (GPC), differential scanning calorimetry (DSC), wide angle X-ray powder-diffraction, and thermal gravimetric analysis (TGA). In vitro studies showed that all the copolymers are degradable in phosphate buffer at 37 °C. The release profiles of hydrophilic model drug, ciprofloxcin hydrochloride, from the copolymers, follows first order release kinetics. All the preliminary results suggested that the copolymer might be potentially used as drug delivery devices.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
