Abstract
EDITORIAL article Front. Immunol., 15 November 2013Sec. Inflammation Volume 4 - 2013 | https://doi.org/10.3389/fimmu.2013.00345
Highlights
Ehlers and Schaible (3) give an overview of the M.tb granuloma research and the host-pathogen interaction
The pathogen-induced strong TH1 type inflammation causes pathology: caseation, cavitation that allow the escape of the bacilli to infect a new host
Guirado and Schlesinger (7) confirm the protective role of the Th1-induced M.tb granuloma with strong M1 mediated bactericidal kill. They rightly stress the importance of the microenvironment in and around the granulomas that cause a variety of pulmonary pathologies in a single person and they acknowledge the changing dynamics between host and pathogen during the long course of the infection
Summary
Ehlers and Schaible (3) give an overview of the M.tb granuloma research and the host-pathogen interaction. The pathogen-induced strong TH1 type inflammation causes pathology: caseation, cavitation that allow the escape of the bacilli to infect a new host. Shaler et al (4) describe the stages of the M.tb granuloma development with the appearance within the lesions of the non-phagocytic macrophage derivatives: foam, epithelioid, and giant cells. Guirado and Schlesinger (7) confirm the protective role of the Th1-induced M.tb granuloma with strong M1 mediated bactericidal kill.
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