Abstract

Abstract Observations made on sickle cells with phase contrast and with the electron microscope lead to the following conclusions. 1. When the red cell sickles, its oscillatory movements cease. 2. Spherical red cells give rise to a special form of sickle cell. 3. Myelin forms, whether attached to the cell or free, become rigid when the tension of oxygen is reduced. 4. The electron microscope, combined with the technic of moulage, shows that the sickle cell contains striated rod-like structures, which give a characteristic appearance to the surface of the sickle cell. 5. Agglutination by appropriate antisera does not occur to any extent in sickled cells, because these rigid structures do not form myelin forms. This is additional evidence of the importance of the formation of viscous surface layers already described as part of the mechanism of agglutination.

Talk to us

Join us for a 30 min session where you can share your feedback and ask us any queries you have

Schedule a call

Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.