Abstract

Liver metastasis is the most common metastasis pattern of colorectal cancer. In recent years, with the renewal of the concept of diagnosis and treatment, the progress of surgical technology and the diversification of treatment options, the prognosis (overall survival, OS) of patients with colorectal cancer liver metastasis (CRCLM) has also been significantly improved. In this review, we introduced the recent updates of concepts including oligometastases, no evidence of disease (NED), criteria of resectable disease, parenchymal sparing surgery, different types of R1 resection margin, liver first approach, associating liver partition and portal vein ligation for staged hepatectomy (ALPPS), hepatic arterial infusion (HAI), and other novel local treatments, in the care of patients with CRCLM. At the same time, the overall treatment modalities of patients with initial resectable and initial unresectable liver metastases are introduced, including some new advances in neoadjuvant chemotherapy, adjuvant chemotherapy, palliative chemotherapy and targeted drug use strategies. Key words: Colorectal cancer; Liver metastasis; Treatment strategies

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