Abstract
Six years ago Kan and Dozy used restriction fragment length polymorphisms (RFLPs ! to diagnose sickle cell anaemia and in 1980 Botstein et al. predicted that it should be possible to use RFLPs, distributed throughout the genome, as genetic markem in linkage studies 2. In principle, this idea has proved correct, but mapping the human genome on the basis of polymorphic sites which happen to create or des~oy restriction cleavage sites is time consuming and labour intensive. The recent discovery of highly polymorphic regions, consisting of a variable number of repeated sequences, in several different areas of the genome may make it possible to use a single probe to follow the inheritance of several loci and facilitate the mapping of disease loci.
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