Abstract
The underlying statistical exercise in some noninferiority studies is to test a composite null hypothesis of a nonzero difference in the means of two normally distributed populations. These noninferiority studies are often analyzed under equal variances assumption. Unequal variances frequently occur in practice. In this article, we propose a noncentral t-distribution-based generalized test for proving noninferiority in the presence of unequal variances. We provide a simple SAS IML code to calculate the new generalized p-value. We compare the new generalized p-value with that of the Student's central t-distribution-based Tsui–Weerahandi generalized test. We conclude that Tsui–Weerahandi generalized test is conservative.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
