New features of the cerebral hemodynamics of brain arteries in patients with HIV-infection in Uzbekistan

Abstract

We aim to study the cerebral hemodynamic indices of the brain arteries in HIV-infected patients. 56 HIV-infected patients were examined, with verified serological and clinical diagnosis, whose average age was 35.7 ± 1.3 years, among which there were 31 (55.4%) men and 25 (44.6%) women. The state of cerebral hemodynamics and vascular reactivity of the cerebral arteries was studied using standard techniques using sensors of 2, 4, 8 MHz on the Spectromed-300 device (Russia). Cerebral hemodynamic disorders in patients according to the Doppler study showed a decrease in blood flow velocity in the ICA by 24.5 and 33.9%, in the MCA by 25.4 and 34.5%, in the PA - by 24.3 and 44.7%, in OA - by 21.7 and 32.6% (groups 1 and 4, respectively) in relation to the indicators in the control group. There were also signs of an increase in vascular tone in all investigated vessels, according to an increase in the pulsation index (Pi) and circulatory resistance (Ri), on average, 1.5 and 2.3 times in group 1; 1.8 and 2.75 times in 4 groups. An increase in vascular tone suggests the inadequate functioning of dilatatory mechanisms at the capillary bed level, which indicates stress in the mechanisms of adaptation of cerebral vessels, which, if not corrected, can lead to their breakdown and development of dyscirculatory processes in the CNS in HIV-infected patients already at the preclinical stages of the disease.