Abstract
Fluorescent dyes with emission wavelengths in the near-infrared region (NIR) can enable tissue imaging from deeper within the sample than dyes with shorter emission wavelengths. But dyes with emission wavelengths in the so-called NIR-II region, 1,000–1,700 nm, are often not as bright as researchers would like. Wen Shi and coworkers at the Chinese Academy of Sciences now report a family of xanthene-based dyes that fluoresce strongly in the NIR-II ( J. Am. Chem. Soc. 2021, DOI: 10.1021/jacs.1c07711 ). These dyes, which the researchers call VIXs, have a xanthene core that is modified with para-substituted styryls. VIXs with nitrogen-bearing styryls fluoresce at longer wavelengths than VIXs with oxygen-bearing styryls. VIX-4, which fluoresces at wavelengths longer than 1,200 nm, is modified with julolidinestyryl. To demonstrate the dyes’ performance, the researchers used VIX-4 encapsulated in liposomes to image blood circulation in mice. They injected VIX-4 into the tail vein of mice and were
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