Abstract
Two new drugs for tuberculosis are being tested in humans, an important step in addressing the dearth of treatments for the deadly infection. The nonprofit TB Alliance says Phase I studies have started for both TBA-7371, part of a new class of antimicrobials called DprE1 inhibitors, and the oxazolidinone sutezolid. TBA-7371 blocks an enzyme critical for synthesizing the polysaccharides that compose the TB bacteria’s cell wall. Development of DprE1 inhibitors began as part of a research collaboration between TB Alliance and AstraZeneca. In 2014, AstraZeneca shut down the R&D site in Bangalore, India, where TB work was conducted, and the nonprofit continued to pursue the compound class. Sutezolid, meanwhile, has been around since the late 1990s. The compound is an analog of the approved antibiotic linezolid, but with fewer side effects and better potency. The trials are “definitely a step forward,” says Sean Ekins, who is CEO of Collaborations Pharmaceuticals
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