Abstract
The Division of Medicinal Chemistry’s “First-Time Disclosures” symposium, where pharmaceutical companies unveil the structures of their clinical candidates, always draws a crowd. The symposium at the ACS national meeting in San Diego last month was no exception. Hundreds of attendees packed into a convention center room to get a peek at eight new drug candidates from seven different companies. Here, we feature the structures and some of the details presented. AZD7594 Company: AstraZeneca Target: Glucocorticoid receptor: When activated, this receptor regulates the expression of genes involved in the body’s immune system. Modulating it can reduce the inflammatory response that causes asthma. Disease: Asthma, chronic obstructive pulmonary disorder (COPD) Notes: This nonsteroidal compound is based on an earlier clinical candidate, AZD5423, which has the same indazole ether core. AZD7594, however, sits differently in the receptor’s binding pocket so that it may access a cavity where it takes advantage of polar...
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